Tablets: 20 milligrams.
Aciphex is prescribed for:
- Zollinger-Ellison Syndrome (In Which There Is Overproduction Of Acid Caused By Tumors);
- Treating Ulcers Of The Stomach And Duodenum;
- Erosive Or Ulcerative Gastroesophageal Reflux Disease (Gerd);
Aciphex blocks acid production in the stomach. It is prescribed for the short-term (4 to 8 weeks) treatment of sores and inflammation in the upper digestive canal (esophagus). This condition, known as gastroesophageal reflux disease (GERD), is caused by the backflow of stomach acid into the esophagus over a prolonged period of time. Because GERD can be chronic, your doctor may continue to prescribe Aciphex to prevent a relapse after your initial course of treatment and to relieve symptoms of GERD such as heartburn.
Aciphex can also be prescribed for the short-term (up to 4 weeks) treatment of duodenal ulcers (ulcers that form just outside the stomach at the top of the small intestine), and for Zollinger-Ellison syndrome, a disease which causes the stomach to produce too much acid. The drug is classified as a "proton pump inhibitor." It works by blocking a specific enzyme essential to the production of stomach acid. It begins reducing acid within an hour of administration.
Aciphex is sometimes combined with the antibiotics amoxicillin and clarithromycin to treat infections caused by H. pylori, a type of bacteria that lives in the digestive tract and is often associated with recurrent ulcers.
For healing ulcerative or erosive GERD, the recommended dose for adults is 20 milligrams daily for 4-8 weeks. If healing does not occur after 8 weeks, another 8 week course may be considered. The recommended maintenance dose is 20 milligrams daily.
Heartburn due to GERD is treated with 20 milligrams daily for 4 weeks and an additional 4 weeks if symptoms do not resolve.
Ulcers are treated with 20 milligrams daily for 4 weeks.
For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 milligrams daily, and the dose is adjusted based on improvement in symptoms, healing of ulcers, or the effectiveness of acid suppression. Doses of 100 milligrams per day and 60 milligrams twice daily have been prescribed in some patients with Zollinger-Ellison Syndrome.
Tablets should be swallowed whole and should not be crushed, split or chewed. Aciphex can be taken with or without meals since food has little effect on its absorption.
Gastroesophageal Reflux Disease (GERD)
The usual dose is 20 mg once a day for 4 to 8 weeks. For patients who have not healed after 8 weeks, the doctor may prescribe an additional 8-week course of Aciphex therapy.
To Relieve Symptoms or Prevent a Relapse of GERD
The usual dose is 20 mg once a day.
The usual dose is 20 mg taken once daily after the morning meal for a period of up to 4 weeks. Some people may require an additional 4 weeks of treatment.
Combination Drug Treatment to Eliminate H. Pylori
The recommended combination is 20 mg of Aciphex, 1,000 mg of amoxicillin, and 500 mg of clarithromycin taken twice a day for 7 days. It's important to take all three drugs for the entire 7 days. Cutting the treatment short could fail to eliminate the infection and possibly lead to antibiotic resistance.
The usual starting dose is 60 mg once a day, although your doctor may adjust the dose based on your individual need. Doses of up to 100 mg once a day or 60 mg twice a day are sometimes indicated.
Aciphex like other PPIs has few side effects:
- Abnormal Heartbeat;
- Muscle Pain;
Side effects cannot be anticipated. Only your doctor can determine if it is safe for you to continue taking Aciphex. Headache is the most common side effect of Aciphex, occurring in two people out of 100.