Aldactone is a diuretic. Aldactone helps you make more urine and to lose excess water from your body. Aldactone is prescribed to treat patients who make too much aldosterone or have low potassium. Aldactone is prescribed to treat high blood pressure, and edema or swelling from heart, kidney, or liver disease.
Aldactone is prescribed to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone) low potassium levels and in patients with edema (fluid retention) caused by various conditions, including heart, liver, or kidney disease.
Aldactone is in a class of medications called aldosterone receptor antagonists.
Aldactone is prescribed alone or with other drugs to treat high blood pressure.
It causes the kidneys to eliminate unneeded water and sodium from the body into the urine, but reduces the loss of potassium from the body.
Aldactone is contraindicated if you have any of the following conditions:
- High blood level of potassium;
- Kidney disease or trouble making urine;
- Liver disease;
- An unusual or allergic reaction to Aldactone, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
- Tell your doctor and pharmacist if you are allergic to Aldactone any other medications or the ingredients in Aldactone tablets. Ask your pharmacist for a list of the ingredients.
- Tell your doctor if you are taking amiloride (Midamor), potassium supplements, triamterene (Dyrenium). Your doctor may tell you not to take Aldactone if you are taking one or more of these medications.
- Tell your doctor and pharmacist what script and nonscript medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik) aspirin and other nonsteroidal anti-inflammatory medications (NSAIDS) such as ibuprofen (Advil, Motrin), indomethacin (Indocin), and naproxen (Aleve, Naprosyn) barbiturates such as phenobarbital digoxin (Digitek, Lanoxicaps, Lanoxin) diuretics ('water pills') lithium (Eskalith, Lithobid) medications to treat high blood pressure narcotic medications for pain and oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone).
- Tell your doctor if you have kidney disease. Your doctor may tell you not to take Aldactone.
- Tell your doctor if you have or have ever had liver disease.
- Tell your doctor if you are pregnant, or plan to become pregnant. If you become pregnant while taking Aldactone, call your doctor. Do not breastfeed if you are taking Aldactone.
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Aldactone.
Do not take Aldactone with any of the following drugs:
- Drugs for high blood pressure like ACE inhibitors;
- Skeletal muscle relaxants like tubocurarine;
- NSAIDs, drugs for pain and inflammation, like ibuprofen or naproxen;
- Potassium products like salt substitute or supplements;
- Pressor amines like norepinephrine;
- Some diuretics;
Aldactone side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat;
- Black or tarry stools;
- Fast, irregular heartbeat;
- Muscle pain, cramps;
- Numbness, tingling in hands or feet;
- Trouble breathing;
- Trouble passing urine;
- Unusual bleeding;
- Unusually weak or tired;
- Change in voice or hair growth;
- Dizzy, drowsy;
- Dry mouth, increased thirst;
- Enlarged or tender breasts;
- Irregular menstrual periods;
- Sexual difficulty, unable to have an erection;
- Stomach upset;
- Stomach pain or cramps;
- Dry mouth;
- Enlarged or painful breasts in men or women;
- Irregular menstrual periods;
- Vaginal bleeding in post-menopausal ('after the change of life' the end of monthly menstrual periods) women;
- Difficulty maintaining or achieving an erection;
- Deepening of voice;
- Increased hair growth on parts of the body;
- Muscle weakness pain or cramps;
- Pain burning numbness or tingling in the hands or feet;
- Inability to move arms or legs;
- Changes in heartbeat;
- Extreme tiredness;
- Unusual bleeding or bruising;
- Lack of energy;
- Loss of appetite;
- Pain in the upper right part of the stomach;
- Yellowing of the skin or eyes;
- Fever sore throat cough chills and other signs of infection;
- Flu-like symptoms;
- Cold gray skin;
- Difficulty breathing or swallowing;
- Vomiting blood;
- Blood in stools;
- Decreased urination;
- Blurred vision;
Reported Aldactone overdose symptoms are:
- Tingling in arms and legs;
- Loss of muscle tone;
- Weakness or heaviness in legs;
- Lack of energy;
- Cold gray skin;
Initial dosages of this medication are prescribed to determine the presence of primary hyperaldosteronism (too much secretion of the adrenal hormone aldosterone). People can be tested with this medication over either a long or a short period of time.
In the long test, you take 400 mg per day for 3 to 4 weeks. If your potassium levels and blood pressure are corrected with this dosage in this time period, your physician may assume you have this condition.
In the short test, you receive 400 mg per day for 4 days. A laboratory test compares potassium levels while you are on Aldactone, Spironolactone, Spirotone and after the medication is stopped. Your doctor may then make a diagnosis.
After the diagnosis of primary hyperaldosteronism is made and confirmed by more tests, the usual dose is 100 to 400 mg per day, prior to surgery. In those who are not good candidates for surgery, this drug is given over the long term at the lowest effective dose.
Fluid Retention (Congestive Heart Failure, Cirrhosis of the Liver, or Kidney Disorders)
The usual starting dosage is 100 mg daily either in a single dose or divided into smaller doses. However, your doctor may have you take daily doses as low as 25 mg or as high as 200 mg.
Your doctor may choose to adjust your dosage after an initial 5-day trial period or add another diuretic medication to this one.
Essential Hypertension (High Blood Pressure)
The usual starting dosage is 50 to 100 mg daily in a single dose or divided into smaller doses. This medication may be given with another diuretic or with other high blood pressure medications.
It may be up to 2 weeks before the full effect of this medication is seen. Your doctor can then adjust the dosage according to your response.
Hypokalemia (Potassium Loss)
Your doctor may have you take daily dosages of 25 mg to 100 mg when potassium loss caused by the effects of a diuretic cannot be treated by a potassium supplement.