Amaryl helps to treat type 2 diabetes. Treatment is combined with diet and exercise. Amaryl helps your body use insulin better.
Amaryl is contraindicated if you have any of the following conditions:
- Diabetic ketoacidosis;
- Glucose-6-phosphate dehydrogenase deficiency;
- Heart disease;
- Kidney disease;
- Liver disease;
- Severe infection or injury;
- Thyroid disease;
- An unusual or allergic reaction to Amaryl, sulfa drugs, other drugs, foods, dyes, or preservatives;
- Pregnancy or recent attempts to get pregnant;
- Tell your doctor and pharmacist if you are allergic to Amaryl or any other drugs.
- Tell your doctor and pharmacist what script and nonscript medications you are taking, especially antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), dexamethasone (Decadron), diuretics ('water pills'), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, niacin, oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.
- Tell your doctor if you have or have ever had kidney disease or ketoacidosis.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Amaryl, call your doctor immediately.
Do not take Amaryl with any of the following drugs:
- Drugs for fungal or yeast infections;
- Alcohol containing beverages;
- Aspirin and aspirin-like drugs;
- Female hormones, like estrogens or progestins and birth control pills;
- Heart drugs like disopyramide;
- Male hormones or anabolic steroids;
- Drugs called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl;
- Drugs for allergies, asthma, cold, or cough;
- Drugs for mental problems;
- Drugs for weight loss;
- NSAIDs, drugs for pain and inflammation, like ibuprofen or naproxen;
- Quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin;
- Some herbal dietary supplements;
- Steroid drugs like prednisone or cortisone;
- Thyroid drug;
- Water pills or diuretics;
Amaryl side effects that you should report to your health care professional or doctor as soon as possible:
- Breathing difficulties;
- Dark yellow or brown urine or yellowing of the eyes or skin;
- Fever, chills, sore throat;
- Low blood sugar (ask your doctor or healthcare professional for a list of these symptoms);
- Severe skin rash, redness, swelling, or itching;
- Unusual bleeding or bruising;
- Nausea, vomiting;
- Stomach discomfort;
- Extreme thirst;
- Frequent urination;
- Extreme hunger;
- Blurred vision;
- Dry mouth;
- Upset stomach and vomiting;
- Shortness of breath;
- Breath that smells fruity;
- Decreased consciousness;
- Dizziness or lightheadedness;
- Nervousness or irritability;
- Sudden changes in behavior or mood;
- Numbness or tingling around the mouth;
- Pale skin;
- Clumsy or jerky movements;
The usual starting dose is 1 to 2 mg taken once daily with breakfast or the first main meal. The maximum starting dose is 2 mg.
If necessary, your doctor will gradually increase the dose 1 or 2 mg at a time every 1 or 2 weeks. Your diabetes will probably be controlled on 1 to 4 mg a day; the most you should take in a day is 8 mg. If the maximum dose fails to do the job, your doctor may add Glucophage to your regimen.
Weakened or malnourished people and those with adrenal, pituitary, kidney, or liver disorders are particularly sensitive to hypoglycemic drugs such as Amaryl, Glimepiride, Betaglim and should start at 1 mg once daily. Your doctor will increase your medication based on your response to the drug.
Safety and effectiveness in children have not been established.