Bupropion is prescribed to help relieve major depression. Symptoms include a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and sometimes, suicidal thoughts or behavior.
Bupropion is thought to work by altering levels of the brain chemicals norepinephrine and dopamine. It is not chemically related to other antidepressants such as tricyclics (Elavil), MAO inhibitors (Nardil, Parnate), or serotonin re-uptake inhibitors (Paxil and Prozac).
Bupropion side effects that you should report to your health care professional or doctor as soon as possible:
- Weight Loss;
- Sore Throat;
- Sleep Disturbances;
- Skin Rash;
- Ringing In The Ears;
- Muscle Soreness;
- Increased Urination;
- Heart Palpitations;
- Excessive Sweating;
- Dry Mouth;
- Abdominal Pain;
No single dose of Bupropion should exceed 150 mg.
At the beginning, your dose will probably be 200 mg per day, taken as 100 mg 2 times a day. After at least 3 days at this dose, your doctor may increase the dosage to 300 mg per day, taken as 100 mg 3 times a day, with at least 6 hours between doses. This is the usual adult dose. The maximum recommended dosage is 450 mg per day taken in doses of no more than 150 mg each.
The usual starting dose is 150 mg in the morning. After 3 days, if you do well, your doctor will have you take another 150 mg at least 8 hours after the first dose. It may be 4 weeks before you feel the benefit and you will take the drug for several months. The maximum recommended dose is 400 mg a day, taken in doses of 200 mg each.
If you have severe cirrhosis of the liver, your dosage should be no more than 75 mg once a day. With less serious liver and kidney problems, the dosage will be reduced as needed.
The usual starting dose is 150 mg taken once a day in the morning. If this dose is well tolerated after a minimum of 3 days, the doctor may increase the dose to 300 mg, also taken once a day in the morning. If no improvement is seen after several weeks of treatment, the doctor may increase the dose to a maximum of 450 mg once a day.
If you have severe liver damage, use this drug with extreme caution. Your dose should not exceed 150 mg every other day. People with mild to moderate liver damage or kidney impairment will be prescribed a lower dose as well.
The safety and effectiveness in children under 18 years old have not been established.