Captopril does not cure high blood pressure it merely keeps it under control.
Captopril is prescribed in the treatment of high blood pressure.
Captopril, the ACE inhibitor, works by preventing a chemical in your blood called angiotensin I from converting into a more potent form that increases salt and water retention in your body. Captopril enhances blood flow throughout your blood vessels.
Hydrochlorothiazide, the diuretic, helps your body produce and eliminate more urine, which helps in lowering blood pressure.
It combines an ACE inhibitor with a thiazide diuretic.
Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Captopril and you must continue taking it even if you are feeling well.
You must take Captopril regularly for it to be effective.
Captopril side effects that you should report to your health care professional or doctor as soon as possible:
More common side effects may include:
- Low blood pressure;
- Loss of taste;
Less common or rare side effects may include:
- Weak or irregular heartbeat;
- Stomach irritation;
- Skin inflammation and/or peeling;
- Severe allergic reactions;
- Sensitivity to light;
- Raynaud's Syndrome (circulatory disorder);
- Rapid heartbeat;
- Peptic ulcer;
- Or throat);
- Muscle weakness;
- Muscle spasm;
- Muscle pain or cramps;
- Low potassium levels leading to symptoms such as dry mouth;
- Loss of appetite;
- Lack of coordination;
- Labored breathing;
- Inflammation of tongue;
- Inflammation of nose;
- Inability to sleep;
- Heart failure;
- Heart attack;
- Hair loss;
- General feeling of ill health;
- Excessive thirst;
- Dry mouth;
- Dizziness upon standing up;
- Chest pain;
- Changes in heart rhythm;
- Breast development in males;
- Blurred vision;
- Angioedema (swelling of the arms and legs;
- Angina pectoris (severe chest pain);
- Abdominal pain;
Captopril is contraindicated if you have any of the following conditions:
- If you notice a yellowish color in your skin or the whites of your eyes;
- If you have liver disease or a disease of the connective tissue called lupus erythematosus;
- If you have impaired kidney function, Captopril should be prescribed only if you have taken other blood pressure medications;
- If you have congestive heart failure;
- If you have a history of angioedema (swelling of face, extremities, and throat) or inability to urinate;
- If you develop swelling of your face around your lips, tongue, or throat, or in your arms and legs;
- If you develop a sore throat or fever you should contact your doctor immediately;
- If you begin to have difficulty swallowing;
- If you are sensitive to other sulfonamide-derived drugs;
- If you are sensitive to or have ever had an allergic reaction to captopril, hydrochlorothiazide, other ace inhibitors such as vasotec, or other thiazide diuretics such as diuril;
Do not take Captopril with any of the following drugs:
- Sulfinpyrazone (anturane);
- Salt substitutes containing potassium;
- Probenecid (benemid);
- Potassium-sparing diuretics such as moduretic;
- Potassium supplements such as slow k;
- Other blood pressure drugs such as hytrin and minipress;
- Oral blood thinners such as coumadin;
- Norepinephrine (levophed);
- Nonsteroidal anti-inflammatory drugs such as naprosyn;
- Nitroglycerin or other nitrates such as transderm-nitro;
- Narcotics such as percocet;
- Methenamine (mandelamine);
- Mao inhibitors (antidepressants such as nardil);
- Lithium (lithonate);
- Heart medications such as lanoxin;
- Diazoxide (proglycem);
- Diabetes medications such as micronase and insulin;
- Corticosteroids such as prednisone (deltasone);
- Colestipol (colestid);
- Cholestyramine (questran);
- Cardiac glycosides such as lanoxin;
- Barbiturates such as phenobarbital or seconal;
- Antigout drugs such as zyloprim;
This medication can be prescribed in conjunction with other blood pressure medications such as beta blockers.
Dosages of this drug are always individualized, and your doctor will determine what combination works best for you.
Dosages are adjusted for people with decreased kidney function.
If this is not effective, your doctor may adjust the dosage upward every 6 weeks.
The initial dose is one 25 milligram/15 milligram tablet, once a day.
The maximum recommended daily dose of hydrochlorothiazide is 50 milligrams.
In general, the daily dose of captopril should not exceed 150 milligrams.
Your doctor will determine the dosage according to your particular needs.
Captopril should be prescribed in children only if other measures for controlling blood pressure have not been effective.
The safety and effectiveness of Captopril in children have not been established.
The symptoms of Captopril overdose may include:
- Stomach and intestinal irritation and hyperactivity;
- Low blood pressure;