Tablets: 25 milligrams,
Tablets: 100 milligrams.
Clozaril is prescribed in the management of psychotic disorders including schizophrenia.
Clozaril is given to help people with severe schizophrenia who have failed to respond to standard treatments. It is prescribed to help reduce the risk of suicidal behavior in people with schizophrenia. Clozaril is not a cure, but it can help some people return to more normal lives.
Clozaril is given once, twice, or three times daily. The dose often is increased slowly until the optimal dose is found. The full effects of Clozaril may not be seen until several weeks after treatment is begun.
Your doctor will carefully individualize your dosage and monitor your response regularly.
The usual recommended initial dose is half of a 25-mg tablet (12.5 mg) 1 or 2 times daily. Your doctor may increase the dosage in increments of 25 to 50 mg a day to achieve a daily dose of 300 to 450 mg by the end of 2 weeks. Dosage increases after that will be only once or twice a week and will be no more than 100 mg each time. Dosage is increased gradually because rapid increases and higher doses are more likely to cause seizures and changes in heart rhythm. The most you can take is 900 mg a day divided into 2 or 3 doses.
Your doctor will determine long-term dosage depending upon your response and results of the regular blood tests.
Safety and efficacy have not been established for children up to 16 years of age.
Among elderly patients with dementia-related psychosis, treatment with
Clozaril is associated with an increased risk of death for unclear
reasons. Clozaril is not approved for use in dementia-related
Seizures have occurred in approximately 1 of every 20 to 30
persons receiving Clozaril . Patients receiving higher doses seem to be
at higher risk.
Dizziness may occur in 1 of 5 persons taking Clozaril . In some cases this may be due to orthostatic
hypotension, a marked decrease in blood pressure that occurs when going from a
lying or sitting position to a standing position. The drop in blood
pressure may lead to loss of consciousness or even cardiac and respiratory
arrest. This reaction is more common during the first few weeks of therapy
while the dose is increasing, when drug is stopped briefly, or when patients are taking benzodiazepines such as diazepam (Valium) or other anti-psychotic drugs.
The most common side effect of Clozaril is
Other side effects include:
- Increased Heart Rate;
- Increased Salivation;
- Low Blood Pressure;
Clozaril has anticholinergic effects that interfere with the function of
smooth muscles. This can lead to blurred vision and difficulty urinating
(when there is enlargement of the prostate) due to effects on the muscles
of the eye and bladder. Clozaril slows the intestine and leads to
constipation in approximately 14% of patients. Paralysis of the intestinal
muscles can lead to paralytic ileus, a condition in which the intestine
Clozaril also may cause extrapyramidal effects (sudden, often
jerky, involuntary motions of the head, neck, arms, body, or eyes).
Like other anti-psychotics, Clozaril also may cause tardive dyskinesia
(potentially irreversible involuntary movements). The risk of such reactions
appears to be lower with Clozaril than with older anti-psychotics,
perhaps due to its weaker effects on dopamine type 2 receptors.
Clozaril side effects that you should report to your health care professional or doctor as soon as possible:
- Weight Gain;
- Vision Problems;
- Rapid Heartbeat And Other Heart Conditions;
- Low Blood Pressure;
- Loss Or Slowness Of Muscle Movement;
- Inability To Sit Down;
- High Blood Pressure;
- Dry Mouth;
- Disturbed Sleep;
- Blood Disorders;
- Abdominal Discomfort;