Depen Penamine is a chelating agent. It attaches to other chemicals in the body, which aids in their removal and is prescribed to remove excess copper associated with Wilson's disease. It is also prescribed to reduce cystine in the urine and to treat severe rheumatoid arthritis.
Contact the doctor immediately if you develop fever; chills; a sore throat; unusual bruising or bleeding; blood in your urine, unexplained shortness of breath, coughing, or wheezing; muscle weakness; or double vision. These symptoms could be early signs of dangerous side effects. You cannot take penicillamine if you have taken it in the past and it has damaged your blood cells. Before taking Depen Penamine, tell your doctor if you have kidney disease or any other serious illness. You may not be able to take Depen Penamine, or you may require a lower dose or special monitoring during therapy. Depen Penamine may cause birth defects in an unborn baby. However, it has also been prescribed during pregnancy with no evidence of defects. Depen Penamine should not be prescribed during pregnancy except to treat Wilson's disease and some cases of cystine in the urine. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether Depen Penamine passes into breast milk. Since Depen Penamine may harm a nursing infant, breast-feeding is not recommended during treatment with this medication.
Do not take Depen Penamine if you are taking any of the following medicines: a gold-therapy product such as auranofin (Ridaura), aurothioglucose (Solganal), or gold sodium thiomalate (Myochrysine, Aurolate); -an antimalarial medicine such as quinine (Quinamm), mefloquine (Lariam), chloroquine (Aralen), hydroxychloroquine (Plaquenil), primaquine, or pyrimethamine (Daraprim); -a cancer chemotherapy medicine; Like Depen Penamine, the medications listed above can affect the blood and the kidneys. Combined with Depen Penamine, any of these medicines can be very dangerous. Before taking Depen Penamine, tell your doctor if you are taking digoxin (Lanoxin, Lanoxicaps). Depen Penamine may decrease the effects of digoxin, and your doctor may want to adjust your dosage or monitor your therapy.
The following side effects can be encountered: allergic reactions (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives); -fever or chills; - a sore throat; - unusual bleeding or bruising; - blood in the urine; - unexplained shortness of breath, coughing, or wheezing; - abdominal pain; - yellow skin or eyes; - muscle weakness; Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual.
Immediately contact emergency medical personnel. Symptoms of a Depen Penamine overdose are not available. Take the missed dose on an empty stomach as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor. If you have missed several doses in a row, do not take any more doses without first talking to your doctor.
Depen Penamine should be taken exactly as directed by your doctor. Take each dose with a full glass of water. Depen Penamine must be taken on an empty stomach, at least 1 hour before or 2 hours after a full meal, and at least 1 hour before or after any other drug, food, or milk. Taking Depen Penamine with anything else in the stomach greatly decreases its effectiveness. Do not stop taking Depen Penamine without first talking to your doctor. Stopping therapy may cause your body to react abnormally when therapy is restarted. If you do stop taking the medication, do not restart without first talking to your doctor. You may need special monitoring. Follow your doctor's instructions. Store Depen Penamine at room temperature away from moisture and heat.
Other Brand Names
In some countries Depen may also be known as: