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Glucophage is prescribed to treat type 2 diabetes. Glucophage helps to control blood sugar. Treatment is combined with diet and exercise. Glucophage can be prescribed alone or with other drugs for diabetes.
Glucophage also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood.
Glucophage decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver.
Glucophage helps to control the amount of glucose (sugar) in your blood.
Glucophage is prescribed alone or with other drugs, including insulin, to treat type 2 diabetes.
Glucophage is not prescribed to treat type 1 diabetes.


Glucophage is contraindicated if you have any of the following conditions:
- Anemia;
- Frequently drink alcohol-containing beverages;
- Become easily dehydrated;
- Heart attack;
- Heart failure that is treated with medications;
- Kidney disease;
- Liver disease;
- Polycystic ovary syndrome;
- Serious infection or injury;
- Vomiting;
- An unusual or allergic reaction to Glucophage, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
- Breast-feeding;
- Tell your doctor and pharmacist if you are allergic to Glucophage or any other medications.
- Tell your doctor and pharmacist what other script and nonscript medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiloride (Midamor, Moduretic) antihistamines beta-blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal) calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan) cimetidine (Tagamet) digoxin (Lanoxin, Lanoxicaps) furosemide (Lasix) hormone replacement therapy insulin or other medications for diabetes isoniazid (INH, Nydrazid) medications for asthma and colds medications for mental illness and nausea such as fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), promethazine (Phenergan), thioridazine (Mellaril), thiothixene (Navane), trifluoperazine (Stelazine), and triflupromazine (Vesprin) medications for thyroid disease morphine (MS Contin, Roxanol, others) nicotinic acid oral contraceptives (birth control pills) oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone) phenytoin (Dilantin, Phenytek) procainamide (Procanbid) quinidine (Quinidex) quinine ranitidine (Zantac) triamterene (Dyazide, Maxzide, others) or trimethoprim (Proloprim, Trimpex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- Tell your doctor if you have or have ever had any medical condition, especially those mentioned in the IMPORTANT WARNING section.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Glucophage, call your doctor.
- If you are using the extended release tablets, you should know that sometimes the tablet shell may appear in your stool. If this occurs, it is not harmful and will not affect the way the medication works.


Do not take Glucophage with any of the following drugs:
- Dofetilide;
- Gatifloxacin;
- Certain contrast drugs given before X-rays, CT scans, MRI, or other procedures;
- Digoxin;
- Diuretics;
- Female hormones, like estrogens or progestins and birth control pills;
- Isoniazid;
- Drugs for blood pressure, heart disease, irregular heart beat;
- Morphine;
- Nicotinic acid;
- Phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine;
- Phenytoin;
- Procainamide;
- Quinidine;
- Quinine;
- Ranitidine;
- Steroid drugs like prednisone or cortisone;
- Stimulant drugs for attention disorders, weight loss, or to stay awake;
- Thyroid drugs;
- Trimethoprim;
- Vancomycin;

Side Effects

Glucophage side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Breathing problems;
- Feeling faint or lightheaded, falls;
- Low blood sugar (ask your doctor or health care professional for a list of these symptoms);
- Muscle aches or pains;
- Slow or irregular heartbeat;
- Unusual stomach pain or discomfort;
- Unusually tired or weak;
- Diarrhea;
- Headache;
- Heartburn;
- Metallic taste in mouth;
- Nausea;
- Stomach gas, upset;
- Diarrhea;
- Bloating;
- Stomach pain;
- Constipation;
- Unpleasant metallic taste in mouth;
- Heartburn;
- Headache;
- Sneezing;
- Cough;
- Runny nose;
- Flushing of the skin;
- Nail changes;
- Muscle pain;
- Extreme thirst;
- Frequent urination;
- Extreme hunger;
- Weakness;
- Blurred vision;
- Dry mouth;
- Upset stomach and vomiting;
- Shortness of breath;
- Breath that smells fruity;
- Decreased consciousness;
- Shakiness;
- Dizziness or lightheadedness;
- Sweating;
- Nervousness or irritability;
- Sudden changes in behavior or mood;
- Headache;
- Numbness or tingling around the mouth;
- Weakness;
- Pale skin;
- Hunger;
- Clumsy or jerky movements;
- Confusion;
- Seizures;


Reported Glucophage overdose symptoms are:
- Extreme tiredness;
- Weakness;
- Discomfort;
- Vomiting;
- Upset stomach;
- Stomach pain;
- Decreased appetite;
- Deep rapid breathing;
- Shortness of breath;
- Dizziness;
- Light-headedness;
- Abnormally fast or slow heartbeat;
- Flushing of the skin;
- Muscle pain;


Your doctor will tailor your dosage to your individual needs.



The usual starting dose is one 500-mg tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily dose by 500 mg at weekly intervals, based on your response up to a total of 2,000 mg.

An alternative starting dose is one 850-mg tablet a day, taken with the morning meal. Your doctor may increase this by 850 mg at 14-day intervals, to a maximum of 2,550 mg a day.

The usual maintenance dose ranges from 1,500 to 2,550 mg daily. If you take more than 2,000 mg a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.

Glucophage XR

The usual starting dose is one 500-mg tablet once daily with the evening meal. Your doctor may increase your dose by 500 mg at weekly intervals, up to a maximum dosage of 2,000 mg a day. If a single 2,000-mg dose fails to control your blood sugar, you may be asked to take 1,000-mg doses twice a day. If you need more than 2,000 mg a day, the doctor will switch you to regular Glucophage.



For children 10 to 16 years old, the usual starting dose is one 500-mg tablet twice a day with meals. The dosage may be increased by 500 mg at weekly intervals up to a maximum of 2,000 mg daily. Glucophage has not been tested in children younger than 10.

Glucophage XR

This form of the drug has not been tested in children younger than 17.


Older people and those who are malnourished or in a weakened state are generally given lower doses of Glucophage because their kidneys may be weaker, making side effects more likely.

(c) 2017