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Glucovance helps to treat type 2 diabetes. Treatment is combined with diet and exercise. Glucovance helps your body to use insulin better.


Glucovance is contraindicated if you have any of the following conditions:
- Diabetic ketoacidosis;
- Glucose-6-phosphate dehydrogenase deficiency;
- Heart disease;
- Kidney disease;
- Liver disease;
- Severe infection or injury;
- Thyroid disease;
- An unusual or allergic reaction to Glucovance, sulfa drugs, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
- Breast-feeding;
- Tell your doctor and pharmacist if you are allergic to Glucovance or any other drugs.
- Tell your doctor and pharmacist what script and nonscript medications you are taking, especially antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), dexamethasone (Decadron), diuretics ('water pills'), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, metformin (Glucophage), niacin (nicotinic acid), oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.
- Tell your doctor if you have or have ever had heart or kidney disease.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Glucovance, call your doctor.
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Glucovance.
- You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
- Remember that alcohol can add to the drowsiness caused by this drug.
- Tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of Glucovance.


Do not take Glucovance with any of the following drugs:
- Bosentan;
- Chloramphenicol;
- Cisapride;
- Clarithromycin;
- Drugs for fungal or yeast infections;
- Metoclopramide;
- Probenecid;
- Rifampin;
- Warfarin;
- Alcohol containing beverages;
- Angiotensin converting enzyme inhibitors like enalapril, captopril, and lisinopril;
- Aspirin and aspirin-like drugs;
- Chloramphenicol;
- Chromium;
- Female hormones, like estrogens or progestins and birth control pills;
- Fluoxetine;
- Heart drugs like disopyramide;
- Isoniazid;
- Male hormones or anabolic steroids;
- Drugs called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl;
- Drugs for allergies, asthma, cold, or cough;
- Drugs for mental problems;
- Drugs for weight loss;
- Niacin;
- NSAIDs, drugs for pain and inflammation, like ibuprofen or naproxen;
- Pentamidine;
- Phenytoin;
- Probenecid;
- Quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin;
- Some herbal dietary supplements;
- Steroid drugs like prednisone or cortisone;
- Thyroid drug;
- Water pills or diuretics;

Side Effects

Glucovance side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Breathing problems;
- Dark urine;
- Fever, chills, sore throat;
- Low blood sugar (ask your doctor or healthcare professional for a list of these symptoms);
- Unusual bleeding or bruising;
- Yellowing of the eyes or skin;
- Diarrhea;
- Headache;
- Heartburn;
- Nausea, vomiting;
- Stomach discomfort;
- Skin rash;
- Itching or redness;
- Exaggerated sunburn;
- Yellowing of the skin or eyes;
- Light-colored stools;
- Dark urine;
- Unusual bleeding or bruising;
- Fever;
- Sore throat;
- Http://wwwfdagov/MedWatch/indexhtml;
- Extreme thirst;
- Frequent urination;
- Extreme hunger;
- Weakness;
- Blurred vision;
- Dry mouth;
- Upset stomach and vomiting;
- Shortness of breath;
- Breath that smells fruity;
- Decreased consciousness;
- Shakiness;
- Dizziness or lightheadedness;
- Sweating;
- Nervousness or irritability;
- Sudden changes in behavior or mood;
- Headache;
- Numbness or tingling around the mouth;
- Weakness;
- Pale skin;
- Hunger;
- Clumsy or jerky movements;
- Confusion;
- Seizures;



Your doctor will start therapy at a low dose and increase it until your blood sugar levels are under control.

For patients not previously treated with diabetes medications

The recommended starting dose is 1.25 mg of glyburide with 250 mg of metformin once or twice daily with meals. The dosage can be increased every two weeks until blood sugar levels are controlled. The maximum recommended daily dosage of Glucovance for previously untreated patients is 10 mg of glyburide with 2,000 mg of metformin.

For patients previously treated with glyburide (or a similar drug) or metformin:

The recommended starting dose of Glucovance is either 2.5 or 5 mg of glyburide with 500 mg of metformin twice daily with meals. The maximum recommended daily dosage of Glucovance for previously treated patients is 20 mg of glyburide with 2,000 mg of metformin.


Glucovance is not for use in children.


Since kidney function declines with age, it should be closely monitored in people taking Glucovance after age 65. Older patients are usually not prescribed the maximum recommended dose of Glucovance.

(c) 2017