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Abruptly stopping Hydrochlorothiazide could cause chest pain, heart rhythm problems, and even heart attack.
Beta-blockers decrease the force and rate of heart contractions, thus lowering blood pressure.
Diuretics help your body produce and eliminate more urine, which helps lower blood pressure.
Do not stop taking Hydrochlorothiazide unless instructed to do so by your doctor.
It combines a beta-blocker (bisoprolol, which is the ingredient in the drug Zebeta) with a thiazide diuretic (hydrochlorothiazide).
Therefore, you must continue taking it even if you are feeling well.
This is especially important if you have coronary artery disease.
Hydrochlorothiazide does not cure high blood pressure it merely keeps it under control.
Hydrochlorothiazide is prescribed to treat high blood pressure.

Side Effects

Hydrochlorothiazide side effects that you should report to your health care professional or doctor as soon as possible:

More common side effects may include:
- Fatigue;
- Dizziness;

Less common side effects may include:
- Muscle cramps;
- Insomnia;
- Impotence;
- Diarrhea;
- Cough;

Rare side effects may include:
- Swelling of the extremities;
- Slow heartbeat;
- Runny nose;
- Restricted blood flow to the extremities;
- Nausea;
- Loss of libido;
- Indigestion;
- Headache;
- Drowsiness;
- Chest pain;


Hydrochlorothiazide is contraindicated if you have any of the following conditions:
- If you develop breathing problems or an extremely slow heartbeat while taking Hydrochlorothiazide;
- If you have a history of congestive heart failure;
- If you have a history of severe allergic reactions that have required epinephrine;
- If you have a slow heartbeat;
- If you have an allergic reaction to the drug or if you're allergic to antibiotics known as sulfonamides (such as bactrim, cotrim, and septra);
- If you have bronchial asthma;
- If you have certain types of irregular heartbeat;
- If you have inadequate blood supply to the circulatory system (cardiogenic shock);
- If you have severe congestive heart failure;
- If you have systemic lupus erythematosus;
- If you have trouble urinating;
- If you suffer from asthma or other bronchial conditions, coronary artery disease, peripheral vascular disease, or kidney or liver disease;
- In a small number of people, Hydrochlorothiazide has interfered with the functioning of the parathyroid, causing blood levels of calcium and phosphate to rise. in rare cases, the drug has caused gout;

if you develop any of the following:
- An unusual decrease in urination;
- Drowsiness;
- Dry mouth;
- Excessive thirst;
- Gastrointestinal problems such as nausea and vomiting;
- Low blood pressure;
- Muscle pains or cramps;
- Rapid heartbeat;
- Restlessness;
- Weakness or muscle fatigue;


Do not take Hydrochlorothiazide with any of the following drugs:
- Alcohol;
- Any other blood pressure drugs, including the calcium-blockers diltiazem (cardizem), disopyramide (norpace), and verapamil (calan);
- Barbiturate sedatives such as seconal and nembutal;
- Cholesterol-lowering drugs such as colestid and questran;
- Clonidine (catapres);
- Diabetes drugs (oral);
- Disopyramide (norpace) and similar drugs prescribed to treat irregular heartbeat;
- Epinephrine (epipen);
- Guanethidine (ismelin);
- Insulin;
- Lithium (eskalith, lithobid);
- Muscle relaxants such as tubocurarine;
- Nonsteroidal anti-inflammatory drugs such as aspirin, motrin, or tylenol;
- Norepinephrine;
- Painkillers such as codeine or morphine;
- Reserpine;
- Rifampin (rifadin);
- Steroids such as prednisone;



Dosage is tailored to each individual's needs.
Extreme caution should be prescribed if the dose has to be increased.
The usual starting dose is 2.5 milligrams of bisoprolol with 6.25 milligrams of hydrochlorothiazide once a day.
If you have asthma, bronchial problems, or kidney or liver disease, the doctor may have you take a very low starting dose.
If this dose is ineffective, the dose may be increased every 14 days up to a maximum of 20 milligrams bisoprolol/12.5 milligrams hydrochlorothiazide once a day.
Hydrochlorothiazide has not been adequately studied in children.


Symptoms of Hydrochlorothiazide overdose may include:
- Weakness;
- Vomiting;
- Thirst;
- Swelling of the legs;
- Slow or rapid heartbeat;
- Shock;
- Nausea;
- Low blood sugar;
- Low blood pressure;
- Impaired consciousness;
- Fluid or electrolyte loss;
- Feet;
- Fatigue;
- Drowsiness;
- Dizziness;
- Difficult or labored breathing;
- Decreased or increased urination;
- Cramps in the calf muscle;
- Congestive heart failure (marked by sudden weight gain;
- Confusion;
- And shortness of breath);
- And ankles;
- Abnormal skin sensations;
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