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A buildup occurs when the body either fails to make enough insulin or doesn't respond to it properly.
Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness and circulation problems, as well as sexual function problems (impotence).
Diabetes develops when the body's ability to burn sugar declines and the unused sugar builds up in the bloodstream.
Metformin is a combination of 2 drugs--glyburide (DiaBeta, Micronase) and metformin (Glucophage)--that attack high blood sugar levels in several ways.
Metformin is an anti-diabetic medication which is a combination of two drugs (sulfonylurea and biguanide).
Metformin is prescribed in the treatment of type 2 (noninsulin dependent) diabetes.
Metformin is prescribed to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes).
Metformin is prescribed when diet and exercise prove insufficient to keep sugar levels under control.
Metformin works by stimulating the release of your body's natural insulin and by restoring your body's proper response to insulin.
Sugar is moved out of the blood and into the body's cells by the hormone insulin.
The glyburide component stimulates the pancreas to produce more insulin and helps the body use it properly.
The metformin component encourages proper insulin utilization, and in addition works to decrease sugar production and absorption.

Side Effects

Metformin side effects that you should report to your health care professional or doctor as soon as possible:
- Blurred vision;
- But seek immediate medical attention if it occurs Symptoms of a serious allergic reaction include: rash;
- Cold sweat;
- Confusion;
- Dark urine;
- Diarrhea;
- Dizziness;
- Drowsiness;
- Easy bleeding or bruising;
- Eat a quick source of sugar such as table sugar;
- Eat meals on a regular schedule and do not skip meals Symptoms of high blood sugar (hyperglycemia) include thirst;
- Etc) The symptoms include chills;
- Fainting;
- Flushing;
- Fruit;
- Headache;
- Honey;
- Hunger;
- Increased urination;
- Itching;
- Juices;
- Mental/mood changes;
- Nausea;
- Or candy;
- Or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level Tell your doctor immediately about the reaction To help prevent hypoglycemia;
- Or fruity breath odor If these symptoms occur;
- Or hunger It is a good habit to carry glucose tablets or gel to treat low blood sugar If you are in a situation where you don't have these reliable forms of glucose;
- Or weight gain may occur initially as your body adjusts to the medication A late recurrence of stomach symptoms may be due to lactic acidosis Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: persistent sore throat or fever;
- Rapid breathing;
- Rapid heartbeat;
- Seizures Metformin can cause low blood sugar (hypoglycemia) This effect may occur if you do not consume enough calories (from food;
- Severe stomach pain;
- Shakiness;
- Shaking;
- Stomach pain;
- Stomach upset;
- Swelling of the hands or feet;
- Swelling;
- Tell your doctor immediately Your medication dosage may need to be increased A serious allergic reaction to Metformin is unlikely;
- Tingling of the hands or feet;
- Trouble breathing;
- Unusual or sudden weight gain;
- Unusual tiredness or weakness;
- Upper respiratory infections;
- Vomiting;
- Weakness;
- Yellowing eyes or skin;


Metformin is contraindicated if you have any of the following conditions:
- if you experience severe vomiting, diarrhea, fever, or if your fluid intake is significantly reduced;
- if you have a heart condition;
- if you have a lack of body fluids (dehydration);
- if you have breathing trouble or rapid breathing;
- if you have cold skin;
- if you have ever had an allergic reaction to metformin, glyburide, or diabetes medications similar to glyburide;
- if you have excessive alcohol use;
- if you have kidney disease or your kidney function has been impaired by a condition;
- if you have kidney or liver disease;
- if you have muscle pain;
- if you have unusual tiredness (fatigue) or severe drowsiness;
- if you have unusually slow or irregular heartbeat;
- if you have x-ray or scanning procedures that require an injectable iodinated contrast drug;
- if you need to have an x-ray procedure done;
- if you need to take medicine for congestive heart failure;
- it if you have liver disease;


Do not take Metformin with any of the following drugs:
- warfarin (coumadin);
- thyroid medications such as synthroid;
- sulfa drugs such as bactrim;
- steroids such as prednisone (deltasone);
- probenecid;
- phenytoin (dilantin);
- nonsteroidal anti-inflammatory drugs such as advil, motrin, naprosyn, and voltaren;
- niacin (niacor, niaspan);
- mao inhibitors such as the antidepressants nardil and parnate;
- major tranquilizers such as compazine, stelazine, and thorazine;
- isoniazid (rifamate);
- hydrodiuril, lasix, and other diuretics;
- estrogens such as premarin;
- ciprofloxacin (cipro);
- chloramphenicol (chloromycetin);
- calcium channel blockers (heart medications) such as calan, isoptin, and procardia;
- birth control pills;
- beta-blockers (heart and blood-pressure drugs such as inderal and tenormin);
- airway-opening drugs such as proventil and ventolin;



Metformin is not for use in children.

Your doctor will start therapy at a low dose and increase it until your blood sugar levels are under control.

For patients previously treated with glyburide (or a similar drug) or metformin:

The maximum recommended daily dosage of Metformin for previously treated patients is 20 mg of glyburide with 2,000 mg of metformin.
The recommended starting dose of Metformin is either 2.5 or 5 mg of glyburide with 500 mg of metformin twice daily with meals.

For patients not previously treated with diabetes medications:

The dosage can be increased every two weeks until blood sugar levels are controlled.
The recommended starting dose is 1.25 mg of glyburide with 250 mg of metformin once or twice daily with meals.
The maximum recommended daily dosage of Metformin for previously untreated patients is 10 mg of glyburide with 2,000 mg of metformin.


Older patients are usually not prescribed the maximum recommended dose of Metformin.
Since kidney function declines with age, it should be closely monitored in people taking Metformin after age 65.


Reported Metformin overdose symptoms are:
- Fast/slow/irregular heartbeat;
- Loss of consciousness;
- Rapid or trouble breathing;
- Severe drowsiness;
- Shakiness;
- Sweating;
(c) 2017