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Metoprolol

Structure

Metoprolol-25 Tablets
Each tablet contains Metoprolol Tartrate IP 25

Metoprolol-50 Tablets
Each tablet contains Metoprolol Tartrate IP 50

Metoprolol-100 Tablets
Each tablet contains Metoprolol Tartrate IP 100

Metoprolol Injection
Each ml contains Metoprolol Tartrate IP 1 , Sodium Chloride IP 9 mg and Water for injection q.s. 1 ml

Metoprolol-H Tablets
Each tablet contains Metoprolol Tartrate IP 100 and Hydrochlorothiazide IP 12.5 mg

Metoprolol XR-12.5
Each extended release capsule contains metoprolol succinate equivalent to metoprolol tartrate 12.5

Metoprolol XR-25
Each extended release capsule contains metoprolol succinate equivalent to metoprolol tartrate 25

Metoprolol XR-50
Each extended release capsule contains metoprolol succinate equivalent to metoprolol tartrate 50

Metoprolol XR-100
Each extended release capsule contains metoprolol succinate equivalent to metoprolol tartrate 100

No Prescription

Metoprolol is prescribed for:
- Angina pectoris;
- Cardiac arrhythmias;
- Congestive heart failure;
- Definite or suspected acute myocardial infarction;
- Hypertension;
- Hyperthyroidism and adjunctive management of thyrotoxicosis;
- Migraine prophylaxis;

Metoprolol-H is prescribed in the treatment of hypertension.

Dosage

HYPERTENSION
The usual initial dose is 100 daily in single or divided doses.
The dosage may be increased if necessary, until optimum blood pressure reduction is achieved.

ANGINA PECTORIS
The usual initial dose is 100 daily, given in two divided doses.
If necessary, the dosage may be increased at weekly intervals, until optimum clinical response has been obtained.

CARDIAC ARRHYTHMIAS
Metoprolol tablets: The usual dose is 100-200 daily in divided doses.
If necessary, the dose may be increased.
Metoprolol Injection: Initially up to 5 should be injected intravenously at a rate of 1-2 mg/minute.
The injection can be repeated at 5 minute intervals until satisfactory response has been obtained.
A total dose of 10-15 generally proves sufficient.
Doses of 20 or more are unlikely to result in further therapeutic benefit.

MYOCARDIAL INFARCTION
Early Treatment: During the early phase of definite or suspected acute myocardial infarction, treatment with Metoprolol should be initiated as soon as possible.
Such treatment should be initiated in a coronary care unit immediately after the patientís hemodynamic condition has stabilized.
Treatment in this early phase should begin with the intravenous administration of three bolus injections of 5 of metoprolol each the injections should be given at approximately 2-minute intervals.
During the intravenous administration of Metoprolol, blood pressure, heart rate and electrocardiogram should be carefully monitored.
In patients who tolerate the full intravenous dose (15 ), Metoprolol tablets 50 mg every 6 hours, should be initiated 15 minutes after the last intravenous dose and continued for 48 hours.
Thereafter, patients should receive a maintenance dose of 100 twice daily.
Patients who appear not to tolerate the full intravenous dose should be started on metoprolol either 25 or 50 mg every 6 hours (depending on the degree of intolerance) 15 minutes after the last intravenous dose or as soon as their clinical condition allows.
In patients with severe intolerance, treatment with metoprolol should be discontinued.
Late treatment: Patients with contraindications to treatment during the early phase of suspected or definite myocardial infarction, patients who appear not to tolerate the full early treatment, and patients in whom the physician wishes to delay therapy for any other reason should be started on a lower dose of metoprolol as soon as their clinical condition allows.
Therapy should be continued for at least 3 months. Data from studies with other beta blockers suggest that treatment should be continued for 1-3 years.

HYPERTHYROIDISM
Usual dose is 150-200 daily, in 3-4 divided doses.

MIGRAINE PROPHYLAXIS
Dose is 100-200 daily given in divided doses.

THYROTOXICOSIS
Usual dose is 50 three or four times a day.

Hypertension
The usual initial dosage is 50 to 100 daily in a single dose, whether prescribed alone or added to a diuretic.
The dosage may be increased at weekly (or longer) intervals until optimum blood pressure reduction is achieved.
In general, the maximum effect of any given dosage will be apparent after one week of therapy.
Dosages above 400 per day have not been studied.

Angina Pectoris
The dosage should be individualized.
The usual initial dosage is 100 daily, given in a single dose.
The dosage may be gradually increased at weekly intervals until optimum clinical response has been obtained or there is a pronounced slowing of the heart rate.
Dosages above 400 per day have not been studied.
If treatment is to be discontinued, the dosage should be reduced gradually over a period of 1-2 weeks.

Migraine prophylaxis
The dosage is 100-200 once daily in the morning.

Contraindications

Metoprolol is contraindicated if you have any of the following conditions:
- Anuria or hypersensitivity to this or other sulphonamide-derived drugs;
- Cardiogenic shock;
- Heart block greater than first degree;
- Myocardial infarction patients with heart rate < 45 beats/minute;
- Overt cardiac failure;
- Second or third degree heart block;
- Sinus bradycardia;

Package

- Blister of 10 capsules;
- Strip of 10 tablets;
- Box of 5 ampoules of 5 ml each;
(c) 2017