If it develops, the doctor will have to switch to a different type of blood thinner.
In occasional cases, hemorrhage and necrosis have led to death or permanent disability.
It is prescribed in the prevention and treatment of pulmonary embolism (a clot lodged in an artery serving the lungs), and in the treatment of certain serious heart conditions.
It is prescribed to prevent and treat blood clots in the veins.
Miradon is a blood thinner (an anticoagulant).
Miradon is a powerful drug with serious potential side effects.
Miradon is prescribed only if you cannot take coumarin-type anticoagulants such as Coumadin.
Necrosis usually occurs within a few days of starting Miradon therapy.
Severe necrosis can result in removal of damaged tissue or amputation of a limb.
The benefits of taking it must be weighed against the risks.
The worst potential side effects of Miradon include severe bleeding (hemorrhage) and destruction of skin tissue (necrosis) or gangrene.
Miradon side effects that you should report to your health care professional or doctor as soon as possible:
Side effects may include:
- Yellowed skin and whites of eyes;
- Sore throat;
- Sore mouth;
- Red or peeling skin;
- Purple toes;
- Paralyzed eye muscle;
- Painful erection;
- Necrosis (gangrene);
- Mouth or throat ulcers;
- Minor bleeding;
- Lung inflammation;
- Loss of appetite;
- Liver damage;
- Kidney damage;
- Inability to urinate;
- Hair loss;
- Greasy stools;
- Blurred vision;
- Blood disorders;
- Abnormal healing of broken bones;
- Abdominal cramps;
Miradon is contraindicated if you have any of the following conditions:
- If you or anyone in your family has a history of blood clots moving and causing blockages;
- If you have any symptoms of abnormal bleeding, such as blood in urine; blood in stools or black, tarry stools; bleeding from gums or nose; patches of discoloration or bruises on the arms, legs, or toes; or excessive bleeding from minor cuts;
- If you are taking miradon;
if you have any condition that may increase the danger of hemorrhage, including:
- Vitamin c or k deficiencies;
- Threatened miscarriage;
- Spinal puncture from regional or lumbar block anesthesia;
- Severe kidney or liver disease;
- Severe high blood pressure;
- Recent or planned brain, eye, prostate, or spinal surgery;
- Open wounds;
- Malnutrition or excessive loss of weight;
- Infection or inflammation of the heart;
- Eclampsia, a serious pregnancy disorder producing life-threatening convulsions, or preeclampsia, a toxic condition marked by high blood pressure that can lead to eclampsia;
- Continuous tube drainage of the small intestine;
- Bleeding, ulcers, or inflammation in the stomach or intestines;
- Aneurysm (balloon-like swelling of a blood vessel);
- A recent cerebral hemorrhage (bleeding stroke);
- A bleeding disorder or a tendency to hemorrhage, such as hemophilia, bleeding under the skin, or leukemia;
Do not take Miradon with any of the following drugs:
- Check with your doctor before making any change in the drugs you take, whether script or nonscript;
- Starting or stopping any medication while taking miradon may affect your body's response to the drug, requiring an adjustment in dosage;
- Certain foods affect your body's response to miradon, so get your doctor's approval for any change in your typical diet while taking miradon, and for any vitamins or nutritional supplements you'd like to take;
The usual doses at the start of therapy are 300 milligrams on the first day, 200 milligrams on the second day, and 100 milligrams on the third day.
After the initial doses, you'll be maintained at a level of 25 to 250 milligrams a day.
Your doctor will individualize the dosage of Miradon according to your sensitivity to the drug.
Symptoms of abnormal bleeding include:
- Patches of discoloration or bruises on the skin;
- Excessive bleeding from minor cuts;
- Blood in urine or stools;
- Bleeding from gums or nose;