Although it is not a cure, Mirapex eases the symptoms of Parkinson's disease--a progressive disorder marked by muscle rigidity, weakness, shaking, tremor, and eventually difficulty with walking and talking.
If you are taking Sinemet or Larodopa, Mirapex may allow a reduction in your dosage.
If you suffer from the "on-off" effect that often develops during Parkinson's therapy (symptom-free periods alternating with severe attacks), Mirapex may extend the good "on" times and shorten your "off" periods.
Mirapex is believed to work by boosting the action of whatever dopamine is available.
Parkinson's disease results from a shortage of the chemical messenger dopamine in certain areas of the brain.
The drug can be prescribed with other Parkinson's medications such as Eldepryl, Sinemet, and Larodopa.
Mirapex side effects that you should report to your health care professional or doctor as soon as possible:
More common side effects may include:
- Vision abnormalities;
- Urinary tract infections;
- Nasal inflammation;
- Memory loss;
- Lack of appetite;
- Involuntary movement (jerky motions);
- Increased urination;
- Increased muscle tone;
- Dry mouth;
- Dizziness upon standing;
- Difficulty walking;
- Difficulty breathing;
- Decreased sensitivity to touch;
- Chest pain;
- Abnormal dreams;
Less common side effects may include:
- Weight loss;
- Unfounded suspicions;
- Uncontrollable restlessness;
- Thinking abnormalities;
- Skin disorders;
- Muscle spasms or twitching;
- Inability to hold urine;
- General feeling of illness;
- Difficulty swallowing;
- Decreased sex drive;
Rare side effects may include:
- Severe chest pain (angina);
- Prostate problems;
- Muscular problems;
- Mental illness;
- Lung problems;
- Joint problems;
- Heart problems;
- Heart attack;
- Eye disorders;
- Enlarged abdomen;
- Difficult or painful urination;
- Blood in urine;
- Blood clots;
- Blood circulation problems;
- Abnormal heartbeat;
- Abnormal ejaculation;
Mirapex is contraindicated if you have any of the following conditions:
- If mirapex gives you an allergic reaction;
- If you are over 65 or have an advanced case of parkinson's;
- If you develop muscle aches or soreness after you start mirapex;
- If you find that you're getting drowsy or falling asleep while eating, talking, or watching television;
- If you have a kidney condition;
- If you notice any changes in your eyesight;
Do not take Mirapex with any of the following drugs:
- Verapamil (calan, isoptin);
- Triamterene (dyrenium);
- Sedatives and tranquilizers such as chloral hydrate, codeine products, dalmane, halcion, and phenobarbital;
- Ranitidine (zantac);
- Quinidine (quinidex, quinaglute);
- Metoclopramide (reglan);
- Major tranquilizers such as compazine, haldol, mellaril, navane, prolixin, stelazine, and thorazine;
- Diltiazem (cardizem, dilacor xr);
- Cimetidine (tagamet);
- Carbidopa/levodopa (sinemet);
The safety and effectiveness of this drug in children have not been established.
The usual starting dose is 0.125 milligrams 3 times a day.
Dosage is usually increased gradually to minimize the drug's potential side effects.
If necessary, your doctor may increase the dose every 5 to 7 days until the maximum dose of 4.5 milligrams a day is reached.
If you have kidney disease, the doctor will keep the dosage quite low.
Although there is no information on Mirapex overdose, any medication taken in excess can have dangerous consequences.