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Premarin

No Prescription

Premarin is prescribed for the treatment of such disorders as:
- Advanced androgen-dependent carcinoma of the prostate;
- Hypoestrogenism due to hypogonadism, castration or primary ovarian failure;
- Moderate or severe symptoms of vaginal or vulvar atrophy associated with the menopause;
- Moderate or severe vasomotor symptoms associated with the menopause;
- Prevention of postmenopausal osteoporosis - in carefully selected cases;
- Some types of Breast Cancer;

Premarin is an estrogen replacement drug. The tablets are prescribed to reduce moderate to severe symptoms of menopause, including feelings of warmth in the face, neck, and chest, and the sudden intense episodes of heat and sweating known as "hot flashes." Cenestin tablets, containing a synthetic form of conjugated estrogens, may also be prescribed for these symptoms.

In addition to the symptoms of menopause, Premarin tablets are prescribed for teenagers who fail to mature at the usual rate, and to relieve the symptoms of certain types of cancer, including some forms of breast and prostate cancer.

In addition, either the tablets or Premarin vaginal cream can be prescribed for other conditions caused by lack of estrogen, such as dry, itchy external genitals and vaginal irritation.

Along with diet, calcium supplements, and exercise, Premarin tablets are also prescribed to prevent postmenopausal osteoporosis, a condition in which the bones become brittle and easily broken. Before taking Premarin solely for this purpose, you should carefully consider using alternative, nonestrogen therapies.

The addition of progesterone to estrogen-replacement therapy has been shown to reduce the risk of uterine cancer. Prempro combines estrogen and progesterone in a single tablet taken once daily. Premphase is a 28-day supply of tablets. The first 14 contain only estrogen. The second 14 supply both estrogen and progesterone. Both Prempro and Premphase are prescribed to reduce the symptoms of menopause, including vaginal problems, and to prevent osteoporosis.

Contraindications

Premarin is contraindicated if you have any of the following conditions:
- Asthma;
- Diabetes;
- Epilepsy;
- Gall bladder diseases;
- High level of Bad cholesterol in triglycerides in the blood;
- Hypertension, angina or any heart disorders;
- Hysterectomy;
- Kidney related disorders;
- Liver related disorders;
- Migraines;
- Uterine fibroids;

Interactions

Do not take Premarin with any of the following drugs:
- Tamoxifen;
- Rifampin;
- Primidone;
- Phenytoin;
- Phenobarbital;
- Levothyroxine;
- Insulin, or other diabetes related medicines (such as Glipizide or Glyburide);
- Didanosine;
- Carbamezepine;
- Anticoagulants;

Side Effects

Premarin side effects that you should report to your health care professional or doctor as soon as possible:
- A decrease in the sex drive;
- Abnormal vaginal bleeding;
- Acne or skin changes;
- Allergic reactions (such as difficulty breathing, hives, rashes, swelling of the face, tongue or lips);
- Bloating through water retention;
- Breast lumps;
- Changes in the menstrual cycle;
- Chest pains, shortness of breath;
- Depression;
- Headaches, migraines;
- Increased chance of developing blood clots in the lungs or legs;
- Increased chance of developing Breast Cancer;
- Increased risk of heart attacks or stroke;
- Jaundice;
- Nausea;
- Pain, tenderness and swelling of the abdomen;
- Painful swollen legs;
- Severe headaches, blurred vision, trouble in speech, dizziness;
- Swollen or tender breasts;
- Risk Ofdeveloping cancer of the uterus;
- Throughdevelopment of endometrial hyperplasia;

Premarin side effects that you should report to your health care professional or doctor as soon as possible:
- Vaginal Yeast Infections;
- Skin Tingling;
- Nausea And Vomiting;
- Liver Problems;
- Joint Pain;
- Irregular Vaginal Bleeding Or Spotting;
- Increased Heartbeat;
- High Blood Sugar;
- High Blood Pressure;
- Headache;
- Hair Loss;
- Fluid Retention;
- Enlargement Of Benign Tumors Of The Uterus (Also Called Fibroids);
- Breast Pain;
- Bloating;
- Constipation;
- Abdominal/Stomach Cramps;

Overdose

Reported Premarin overdose symptoms are:
- Nausea;
- Vaginal bleeding;
- Vomiting;

Other Brand Names

In some countries Premarin may also be known as:
- Belestar;
- Biostrogen;
- Cenestin;
- CES;
- Climatrol E;
- Climopax mono;
- Conpremin;
- Dagynil;
- Enjuvia;
- Equin;
- Espauz;
- Estrarona;
- Estrin;
- Estrogenon;
- Estroplus;
- Livomarin;
- Longaplex;
- Menosedan;
- Menostat;
- Oestrofeminal;
- Prem;
- Repogen;

Dosage.

Your doctor will start therapy with this medication at a low dose and adjust the dosage according to your response. He or she will want to check you periodically at 3- to 6-month intervals to determine the need for continued therapy.

Premarin TABLETS

Hot flashes associated with menopause

The usual starting dosage is 0.3 mg daily, taken continuously or in cycles such as 25 days on Premarin and 5 days off.

Tissue degeneration in the vagina

The usual starting dosage is 0.3 mg daily, taken continuously or in cycles.

Low estrogen levels due to reduced ovary function

The usual dosage is 0.3 to 0.625 mg daily, taken cyclically.

Ovary removal or ovarian failure

The usual dosage is 1.25 mg daily, taken cyclically.

Prevention of osteoporosis (loss of bone mass)

The usual starting dosage is 0.3 mg daily, taken continuously or in cycles.

Advanced androgen-dependent cancer of the prostate, for relief of symptoms only

The usual dosage is 1.25 to 2.5 mg 3 times daily.

Breast cancer (for relief of symptoms only) in appropriately selected women and men with metastatic disease

The suggested dosage is 10 mg 3 times daily for a period of at least 3 months. Tell your doctor if you have any unusual bleeding.

Premarin VAGINAL CREAM

Given cyclically for short-term use only.

Degeneration of genital tissue or severe itching in the genital area

The recommended dosage is one-half to 2 grams daily, inserted into the vagina, depending on the severity of the condition. You will use the cream for 3 weeks, then stop for 1 week. Tell your doctor if you notice any unusual bleeding.

PREMPRO TABLETS/PREMPHASE THERAPY

Symptoms associated with menopause (hot flashes, night sweats, and vaginal tissue degeneration) or for the prevention of osteoporosis (loss of bone mass)

The usual starting dose for Prempro is one 0.3-mg/1.5-mg tablet once a day. If this dose proves insufficient, your doctor may increase the dose to one 0.625-mg/0.25- or 0.5-mg tablet once a day.

For Premphase therapy, follow a 28-day cycle. Take 1 maroon Premarin tablet (equal to 0.625 mg estrogen) every day for the first 14 days; on the 15th day, begin taking 1 light-blue tablet (equal to 0.625 mg estrogen/5 mg progesterone) daily.

CENESTIN TABLETS

The usual starting dose is 0.45 mg a day. If this proves insufficient, the doctor may gradually increase the dose up to a maximum of 1.25 mg daily.
(c) 2017