Sandimmune is given after organ transplant surgery to help prevent rejection of organs (kidney, heart, or liver) by holding down the body's immune system. It is also prescribed to avoid long-term rejection in people previously treated with other immunosuppressant drugs, such as Imuran.
Neoral is a newer formulation of Sandimmune's active ingredient, cyclosporine. In addition to prevention of organ rejection, it is prescribed for certain severe cases of rheumatoid arthritis and psoriasis.
Some doctors also prescribe Sandimmune to treat alopecia areata (localized areas of hair loss), aplastic anemia (shortage of red and white blood cells and platelets), Crohn's disease (chronic inflammation of the digestive tract), and nephropathy (kidney disease). Sandimmune is sometimes prescribed in the treatment of severe skin disorders, including psoriasis and dermatomyositis (inflammation of the skin and muscles causing weakness and rash). The drug is also prescribed in procedures involving bone marrow, the pancreas, and the lungs.
Sandimmune is always given with prednisone or a similar steroid. It is available in capsules and liquid, or as an injection.
Sandimmune side effects that you should report to your health care professional or doctor as soon as possible:
- Sinus Inflammation;
- Numbness Or Tingling;
- Nasal Inflammation;
- Lymph System Tumor;
- Liver Damage;
- Flu-Like Symptoms;
- Breathing Difficulty;
- Bone Or Joint Pain;
- Abdominal Discomfort;
Your doctor will tailor your dosage of Sandimmune in accordance with your body's response. Expect a single dose of 15 mg per 2.2 pounds of body weight 4 to 12 hours before a transplant and 1 dose daily for 1 to 2 weeks after the operation. After that, the doctor may keep you on a daily dose of 5 to 10 mg per 2.2 pounds of body weight.
The dosage of Neoral depends on the type of transplant and the other drugs you are taking. It is always taken twice a day.
Psoriasis or Rheumatoid Arthritis
The starting dosage is 2.5 mg of Neoral per 2.2 pounds of body weight divided into 2 doses per day. Your doctor may gradually increase the daily dose to a maximum of 4 mg per 2.2 pounds.
Dosage is generally the same for children as for adults, though somewhat higher doses are sometimes needed. Both drugs have been prescribed to prevent transplant rejection in small children. Neoral has not been tested for arthritis or psoriasis in children under 18.