Tablets: 25 milligrams,
Tablets: 50 milligrams,
Tablets: 100 milligrams,
Tablets: 200 milligrams,
Tablets: 300 milligrams,
Tablets: 400 milligrams.
Seroquel is prescribed alone or in combination with other drugs to treat schizophrenia and bipolar disorder.
Seroquel is prescribed for the treatment of schizophrenia, a mental disorder marked by delusions (false beliefs), hallucinations, disrupted thinking, and loss of contact with reality. It is also prescribed for the short-term treatment of mania associated with bipolar disorder.
Seroquel is the first in a new class of antipsychotic medications. Researchers believe that it works by diminishing the action of dopamine and serotonin, two of the brain's chief chemical messengers.
Seroquel usually is taken two or three times daily. The dose usually is increased slowly over several days
or weeks to achieve the desired effect. Seroquel can be taken with or without
The initial dose for bipolar disorder is 50 milligrams twice daily (100 milligrams/d). The dose
can be increased by 100 milligrams/d to a daily dose of 400 milligrams/d. Most patients respond
to 400-800 milligrams/d. Doses greater than 800 milligrams/d have not been studied.
The initial dose for schizophrenia is 25 milligrams twice daily (50 milligrams/d). The dose
can be increased by 25-50 milligrams two or three times daily. The target dose is
300-400 milligrams/d in two or three doses. Patients respond to 150-750 milligrams/d, and doses
greater than 800 milligrams/d have not been evaluated.
The usual dosage range is 300 to 400 mg a day, divided into two or three smaller doses. Doses as low as 150 mg a day sometimes prove effective, and the dose rarely exceeds 750 mg per day. Doses above 800 mg per day have not been tested for safety. The dose is gradually increased over 4 days until the most effective dose is reached, using the following schedule: Day 1: Take 25 mg twice a day. Days 2, 3, and 4: The doctor will increase each daily dose by 25 to 50 mg, taken either two or three times a day. Day 5 and up: If needed, the doctor may increase each dose by 25 to 50 mg every 2 or more days.
BIPOLAR MANIA (SHORT-TERM TREATMENT OF ACUTE EPISODES)
The usual dosage range is 400 to 800 mg a day. Doses above 800 mg a day have not been tested for safety. The dosage will be gradually increased over 4 to 6 days until the most effective dose is reached, using the following schedule: Day 1: Take 50 mg twice a day. Day 2: The doctor will increase the dose to 100 mg twice a day. Day 3: The doctor will increase the dose to 150 mg twice a day. Day 4: The doctor will increase the dose to 200 mg twice a day. Days 5 and 6: If needed, the doctor may increase each dose by no more than 200-mg increments to a total daily dose of 800 mg.
If you have liver problems, you may be started at 25 mg a day. The doctor will increase the dose as needed in increments of 25 to 50 mg a day based on your body's response.
The dosage may also need to be lowered if you are weak, elderly, or prone to low blood pressure reactions. You may also need your dose adjusted if you're taking certain drugs, including Dilantin, Tegretol, and phenobarbital.
Frequent adverse effects include:
- Stomach upset;
- Weight gain;
Seroquel can cause orthostatic hypotension (a drop in blood pressure upon standing that can lead to
dizziness or fainting) especially during the first 3-5 day period of treatment,
when it is restarted after temporary discontinuation, and after an increase in
the dose. The risk of orthostatic hypotension is about 1 in 100 (one of every
hundred patients who takes Seroquel). Seroquel frequently causes tiredness
(1 in 5 patients), especially during the first 3-5 days of treatment. Because of
this tiredness, care should be exercised in any activity requiring mental
alertness such as operating a motor vehicle or hazardous machinery. Less common
side effects include seizures (1 in 125 patients) and hypothyroidism (1 in 250
As with other antipsychotics, long-term use of Seroquel may lead to
irreversible tardive dyskinesia, a neurologic disease which consists of
involuntary movements of the jaw, lips, and tongue.
A potentially fatal complex referred to as neuroleptic malignant syndrome
(NMS) has been reported with antipsychotic drugs.
Patients who develop NMS may have:
- Altered mental status;
- Excessive sweating;
- Heart arrhythmias;
- High fevers;
- Irregular pulse or blood pressure;
- Muscle rigidity;
- Rapid heart rate;
Seroquel side effects that you should report to your health care professional or doctor as soon as possible:
- Uncontrollable Movements;
- Rapid Or Irregular Heartbeat;
- Neck Rigidity;
- Nasal Inflammation;
- Low Blood Pressure (Especially Upon Standing);
- Excessive Muscle Tone;
- Dry Mouth;
- Diminished Movement;
- Abdominal Pain;