Sinemet is prescribed to treat symptoms of Parkinson's disease. Sinemet is always given with levodopa or Sinemet levodopa combination products.
Sinemet is contraindicated if you have any of the following conditions:
- Heart disease, including history of a heart attack;
- Irregular heart beat;
- Kidney or liver disease;
- Lung disease like asthma;
- Melanoma or suspicious skin lesions;
- Mental problems or depression;
- Stomach or intestine ulcers;
- An unusual or allergic reaction to Sinemet, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
Do not take Sinemet with any of the following drugs:
- Drugs for high blood pressure;
Sinemet side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Anxiety, confusion, or nervousness;
- Fast or irregular heartbeat;
- Feeling faint or lightheaded, falls;
- Mood changes like aggressive behavior, depression;
- Stomach pain;
- Trouble passing urine;
- Uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or other unusual muscle movements;
- Dark color (brown, red, or black) of saliva, urine or sweat;
- Loss of appetite;
- Muscle twitches;
- Nightmares, trouble sleeping;
- Unusually weak ot tired;
Your doctor will tailor your individual dosage carefully, depending on your response to previous therapy and symptoms.
For patients with mild to moderate symptoms, the initial recommended dose is 1 tablet of Sinemet, 25 mg of Carbidopa and 250 mg Of Levodopa CR taken 2 times a day.
Starting doses should be spaced out every 4 to 8 hours and then adjusted to each patient's individual response.
The usual long-term dose is 2 to 8 tablets per day, taken in divided doses every 4 to 8 hours during the waking day.
Higher doses (12 or more tablets per day) and shorter intervals (less than 4 hours) have been used, but are not usually recommended.
When doses of Sinemet, 25 mg of Carbidopa and 250 mg Of Levodopa CR are given at intervals of less than 4 hours, and/or if the divided doses are not equal, it is recommended that the smaller doses be given at the end of the day.
An interval of at least 3 days between dosage adjustments is recommended.
Dosage adjustment of Sinemet, 25 mg of Carbidopa and 250 mg Of Levodopa CR may be necessary if your doctor prescribes additional medications.
Use of Sinemet, 25 mg of Carbidopa and 250 mg Of Levodopa CR in children under 18 is not recommended.