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Tacrolimus

No Prescription

Following an organ transplant the body's immune system recognises that this new organ is 'foreign' to you and will try to attack it with lymphocytes.
Tacrolimus is prescribed for use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.
Tacrolimus is prescribed in a topical preparation in the treatment of severe atopic dermatitis.
Tacrolimus works by stopping the body from producing these lymphocytes and prevents the attack on the transplanted organ.
The body produces white blood cells, called lymphocytes, to fight germs or foreign substances which have entered the body.

Contraindications

Tacrolimus is contraindicated if you have any of the following conditions:
- If you are a woman using a hormonal contraceptive such as the pill, injection, implant or intra-uterine progestogen-only system (IUS);
- If you are pregnant, trying for a baby or breast-feeding;
- If you are taking any other medicines, including those available to buy without a script, herbal and complementary medicines;
- If you have an infection;
- If you have an intolerance to some sugars (AdvagrafR prolonged-release capsules contain lactose);
- If you have cancer;
- If you have ever had an allergic reaction to any of the other ingredients in this medicine, for example polyoxyethylated hydrogenated castor oil or similar oils (PrografR infusion contains polyoxyethylene hydrogenated castor oil);
- If you have ever had an allergic reaction to tacrolimus or any other medicine, especially the antibiotics erythromycin, clarithromycin, azithromycin and telithromycin;
- If you have previously received a drug called ciclosporin;
- If you suffer from alcohol problems (PrografR Infusion contains a small amount of alcohol);
- If you suffer from diabetes;
- If you suffer from epilepsy;
- If you suffer from gout, high levels of potassium in your blood or high blood pressure;
- If you suffer from liver, kidney or heart problems;
- If you suffer from porphyria (a blood disorder);

Side Effects

Tacrolimus side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Abnormal dreams;
- Acne;
- Agitation;
- Angina;
- Anxiety;
- Bloating;
- Blood sugar changes;
- Chest pain or tightness;
- Confusion;
- Constipation;
- Convulsions;
- cough;
- Diarrhoea;
- Dizziness;
- Emotional changes;
- Excess hair growth;
- Excess of body fluid;
- Fast or fluttering heartbeat;
- Feeling depressed;
- Feet;
- Fever;
- Flatulence;
- Flu-like symptoms;
- Hair loss;
- Headache;
- Heart problems;
- increased or decreased blood pressure;
- Indigestion;
- Inflammation or ulcers in the mouth;
- Itching;
- Joint pain;
- Kidney problems;
- Liver problems;
- Loss of appetite;
- Loss of co-ordination;
- Loss of energy or weakness;
- Mental disorders;
- Muscle cramps and stiffness;
- Nausea;
- Nervousness;
- numbness or pain in the legs;
- Pale skin;
- Problems with urination (passing water);
- Seeing or hearing things that are not there;
- Sensitivity to light;
- Shortness of breath;
- Skin rash;
- Swelling of feet or lower legs;
- Tingling;
- Trembling;
- Tremor;
- Trouble sleeping;
- Unusual bleeding or bruising;
- Unusual tiredness;
- Visual disturbances;
- Vomiting;
- Weight loss or weight gain;
- Wheezing;
- Yellowing of skin;

Overdose

Reported Tacrolimus overdose symptoms are:
- Blurred vision;
- Confusion;
- Diabetes mellitus;
- Hyperkalemia;
- Hypertension;
- Hypomagnesemia;
- Insomnia;
- Itching;
- Liver and kidney problems (it is nephrotoxic);
- Seizures;
- Tremors;

Other Brand Names

In some countries Tacrolimus may also be known as:
- Prograf;
- Fujimycin;
- Protopic;
(c) 2017