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Topotecan

No Prescription

Topotecan is a chemotherapy drug.
Topotecan is prescribed to treat cancer of the ovaries or lungs when other treatments have not been successful.
Topotecan is prescribed to treat lung cancer, ovarian cancer, and cervical cancer.
Topotecan is prescribed with another medication (cisplatin) to treat cancer of the cervix.

Side Effects

Topotecan side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- breathing difficulties;
- Constipation;
- Cough;
- Dark urine;
- Diarrhea;
- dizziness;
- fever or chills, sore throat;
- hair loss;
- Headache;
- Itching/swelling (especially of the face/tongue/throat);
- Loss of appetite;
- mouth sores or pain;
- Mouth sores;
- nausea, vomiting;
- Nausea;
- Numbness/tingling of the arms/legs;
- pain, tingling, numbness in the hands or feet;
- Pain/redness/bruising at injection site;
- Rash;
- Severe dizziness;
- Shortness of breath;
- stomach pain;
- Tiredness;
- Trouble breathing;
- unusual bleeding or bruising;
- unusually weak or tired;
- Vomiting;
- Weakness;
- Yellowing eyes/skin;
- yellowing of the eyes or skin;

Contraindications

Topotecan is contraindicated if you have any of the following conditions:
- an unusual or allergic reaction to topotecan, other medicines, foods, dyes, or preservatives;
- blood disorders;
- breast-feeding;
- dehydration;
- diarrhea;
- immune system problems;
- infection (especially a virus infection such as chickenpox, cold sores, or herpes);
- kidney disease;
- low blood counts, like low white cell, platelet, or red cell counts;
- pregnant or trying to get pregnant;
- recent or ongoing radiation therapy;
- if you are allergic to topotecan;
- if you have a certain immune system problem (neutropenia);
- if you have any other allergies;
- if you have blood/bone marrow disorders (low platelet/white blood cell/red blood cell levels);
- if you have certain medical conditions;
- if you have kidney disease;
- if you have liver disease;

Interactions

Do not take Topotecan with any of the following drugs:
- acetaminophen;
- amiodarone;
- antiviral medicines for hiv or aids;
- aspirin;
- cisplatin;
- clarithromycin;
- cyclosporine;
- diltiazem;
- erythromycin;
- grapefruit or grapefruit juice;
- ibuprofen;
- ketoprofen;
- medicines for fungal infections like ketoconazole and itraconazole;
- mefloquine;
- mifepristone, ru-486;
- naproxen;
- nicardipine;
- phenytoin;
- phenytoin;
- propafenone;
- quinidine;
- tacrolimus;
- tamoxifen;
- testosterone;
- vaccines;
- verapamil;

Overdose

Reported Topotecan overdose symptoms are:
- Easy bruising/bleeding;
- Fast/pounding heartbeat;
- Signs of infection (persistent sore throat fever);
- Unusual tiredness;
(c) 2017