It helps relieve the painful leg cramps caused by "intermittent claudication," a condition that results when hardening of the arteries reduces the leg muscles' blood supply.
Some doctors prescribe Trental for dementia, strokes, circulatory and nerve problems caused by diabetes, and Raynaud's syndrome (a disorder of the blood vessels in which exposure to cold causes the fingers and toes to turn white).
The drug is prescribed to treat impotence and to increase sperm motility in infertile men.
Trental can ease the pain in your legs and make walking easier but should not replace other treatments such as physical therapy or surgery.
Trental is a medication that reduces the viscosity or "stickiness" of your blood, allowing it to flow more freely.
Trental side effects that you should report to your health care professional or doctor as soon as possible:
Side effects may include:
- Weight change;
- Stuffy nose;
- Sore throat;
- Sore throat/swollen neck glands;
- Or legs;
- Low blood pressure;
- Loss of appetite;
- Inflammation of the gallbladder;
- General body discomfort;
- Flu-like symptoms;
- Fluid retention;
- Fever and chills;
- Excessive salivation;
- Dry mouth/thirst;
- Difficulty swallowing;
- Difficult or labored breathing;
- Conjunctivitis (pinkeye);
- Chest pain);
- Chest pain (sometimes crushing);
- Brittle fingernails;
- Blurred vision;
- Blind spot in vision;
- Bad taste in the mouth;
- Allergic reaction (symptoms include: swelling of face;
Trental is contraindicated if you have any of the following conditions:
- If you are sensitive to or have ever had an allergic reaction to trental, caffeine, theophylline (medication for asthma or other breathing disorders), or theobromine;
- If you are taking a blood thinner, or have recently had surgery, peptic ulcers, or other disorders that involve bleeding;
- If you have recently had a stroke or bleeding in the retina of your eye;
Do not take Trental with any of the following drugs:
- Ulcer medicines such as tagamet;
- Theophylline (theo-dur);
- Clot inhibitors such as persantine;
- Blood-thinning drugs such as coumadin;
- Blood pressure medications such as vasotec and cardizem sr;
The safety and effectiveness of this drug in children have not been established.
The usual dosage of Trental in controlled-release tablets is one 400-milligram tablet 3 times a day with meals.
While the effect of Trental may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks.
If any of these side effects occur, the dosage should be lowered to 1 tablet, 2 times a day, for a total of 800 milligrams a day.
Any stomach or central nervous system (affecting the brain and spinal cord) side effects are related to the dose.
If side effects persist at this lower dosage, your doctor may consider stopping this drug.
Symptoms of Trental overdose may include:
- Low blood pressure;
- Loss of consciousness;