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Combination products such as Zestoretic are usually not prescribed until therapy is already under way.
Hydrochlorothiazide, a diuretic, prompts your body to produce and eliminate more urine, which helps in lowering blood pressure.
It combines an ACE inhibitor drug with a diuretic.
Lisinopril, the ACE inhibitor, works by limiting production of a substance that promotes salt and water retention in your body.
Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Zestoretic and you must continue taking it even if you are feeling well.
You must take Zestoretic regularly for it to be effective.
Zestoretic does not cure high blood pressure it merely keeps it under control.
Zestoretic is prescribed in the treatment of high blood pressure.
Zestoretic side effects that you should report to your health care professional or doctor as soon as possible:
More common side effects may include:
- Dizziness when standing up;
Less common side effects may include:
- Upper respiratory infection;
- Tingling or pins and needles;
- Muscle cramps;
- Low blood pressure;
- Hair loss;
Rare side effects may include:
- Swelling of the face;
- Stuffy nose;
- Stomach and intestinal cramps;
- Sore throat;
- Skin inflammation;
- Sinus inflammation;
- Shoulder pain;
- Shortness of breath;
- Severe allergic reaction;
- Sensitivity to light;
- Ringing in ears;
- Reduced urine output;
- Red or purple areas on the skin;
- Rapid heartbeat;
- Muscle spasm;
- Muscle pain;
- Lung inflammation or congestion;
- Loss of appetite;
- Knee pain;
- Joint pain;
- Heart rhythm disturbances;
- Heart attack;
- Hay fever;
- General feeling of illness;
- Foot pain;
- Excessive perspiration;
- Dry mouth;
- Difficulty falling or staying asleep;
- Difficulty breathing;
- Decreased sex drive;
- Common cold;
- Chest discomfort or pain;
- Blurred vision;
- Back strain;
- Back pain;
- Abdominal pain;
Zestoretic is contraindicated if you have any of the following conditions:
- If you actually faint;
- If you are diabetic;
- If you are sensitive to other ace inhibitor drugs such as capoten or sulfa drugs such as gantrisin;
- If you are unable to urinate;
- If you are undergoing desensitization to bee or wasp venom, zestoretic may cause a severe allergic reaction;
- If you develop chest pain, a sore throat, or fever and chills;
- If you develop swelling of your face, lips, tongue, or throat, or of your arms and legs, or have difficulty swallowing or breathing;
- If you feel light-headed, especially during the first few days of treatment;
- If you have congestive heart failure or other heart problems, diabetes, liver disease, a history of allergy or bronchial asthma, or lupus erythematosus (an arthritis-like disease sometimes accompanied by rashes);
- If you have kidney disease;
- If you notice a yellowish cast to your skin or eyes;
Do not take Zestoretic with any of the following drugs:
- Potassium-sparing diuretics such as midamor;
- Potassium-containing salt substitutes;
- Potassium supplements such as k-dur and slow-k;
- Oral antidiabetic drugs such as micronase;
- Nonsteroidal anti-inflammatory drugs such as naprosyn;
- Narcotics such as darvon and dilaudid;
- Lithium (lithonate);
- Indomethacin (indocin);
- High blood pressure drugs such as procardia xl and aldomet;
- Corticosteroids such as prednisone;
- Colestipol (colestid);
- Cholestyramine (questran);
- Barbiturates such as nembutal and seconal;
Safety and effectiveness in children have not been established.
Zestoretic is designed to replace higher doses of either component.
Dosages of the lisinopril component range from 10 to 80 milligrams a day dosages of hydrochlorothiazide typically fall between 6.25 and 50 milligrams daily.
If either component, when prescribed alone, fails to control your blood pressure, your doctor may try the Zestoretic combination, starting with either 10 or 20 milligrams of lisinopril and 12.5 milligrams of hydrochlorothiazide, and gradually increasing the dosage as needed.
If you are age 65 or older, or have kidney problems, your doctor will adjust your dosage with caution.
This drug is not prescribed for people with severe kidney damage.
Symptoms of Zestoretic overdose may include:
- Low blood pressure;