Tablets: 5 milligrams,
Tablets: 10 milligrams,
Tablets: 20 milligrams,
Tablets: 40 milligrams.
High blood cholesterol is first treated with exercise, weight loss, and a diet low in cholesterol and saturated fats.
When these measures fail, cholesterol-lowering medications such
as Zocor can be added. The National Cholesterol Education
Program (NCEP) has published treatment guidelines for use of these medications.
These treatment guidelines take into account the level of LDL
cholesterol as well as the presence of other risk factors such as diabetes,
hypertension, cigarette smoking, low HDL cholesterol level, and
family history of early coronary heart disease. The effectiveness of
the medication in lowering cholesterol is dose related. Blood
cholesterol determinations are performed in regular intervals during
treatment so that dosage adjustments can be made.
Zocor is a cholesterol-lowering drug. Your doctor may prescribe Zocor in addition to a cholesterol-lowering diet if your blood cholesterol level is too high, and if you have been unable to lower it by diet alone. For people at high risk of heart disease, current guidelines call for considering drug therapy when LDL levels reach 130. For people at lower risk, the cut-off is 160. For those at little or no risk, it's 190.
In people with high cholesterol and heart disease, Zocor reduces the risk of heart attack, stroke, and "mini-stroke" (transient ischemic attack) and can stave off the need for bypass surgery or angioplasty to clear clogged arteries. Zocor can also reduce these risks in people with diabetes, peripheral vascular disease, and a history of stroke.
Zocor is generally well-tolerated and side effects are rare.
Minor side effects include:
Major side effects include:
- Yellowing of the skin or eyes;
- Muscle pain or cramps;
- Easy bruising or bleeding;
- Blurred vision;
- Abdominal pain or cramps;
Zocor side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal Pain;
You will have to follow a standard cholesterol-lowering diet before starting treatment with Zocor and continue this diet while using Zocor.
All doses should be adjusted to your individual needs.
The usual starting dose is 20 to 40 mg once a day in the evening. If your cholesterol level or heart attack risk is especially high, the doctor may start with a dose of 40 mg. The dosage can be adjusted every 4 weeks. Some people with severe, hereditary high cholesterol may be prescribed as much as 80 mg a day, taken in doses of 20, 20, and 40 mg, along with other treatments.
Those who have severe kidney disease should use Zocor with caution. The recommended starting dose is 5 mg per day.
When combined with cyclosporine, niacin, Atromid-S, Lopid, or Tricor, the dosage of Zocor should not exceed 10 mg a day. When combined with Calan or Cordarone, the dosage of Zocor should not exceed 20 mg a day.
CHILDREN 10 TO 17 YEARS OLD
The recommended starting dose is 10 mg once a day in the evening. The dosage may be increased every 4 weeks, as determined by the doctor, up to a maximum of 40 mg a day. Girls must have been menstruating for at least 1 year before starting therapy with Zocor.
The safety and effectiveness of Zocor in children under 10 years old or in doses greater than 40 mg a day have not been studied.