Tablets: 20 milligrams;
Injection: 10 milligrams.
Zyprexa is prescribed for treating schizophrenia and acute mixed, or manic episodes associated with bipolar disorder.
Zyprexa is prescribed as maintenance therapy for bipolar disorder and treating agitation due to schizophrenia or bipolar disorder.
Zyprexa helps manage symptoms of schizophrenia, the manic phase of bipolar disorder, and other psychotic disorders. It is thought to work by opposing the action of serotonin and dopamine, two of the brain's major chemical messengers. The drug is available as Zyprexa tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid.
The usual oral dose for treating schizophrenia is 10 milligrams once daily. Therapy is initiated with 5-10 milligrams/day and the dose may be increased by 5
milligrams a day in weekly intervals. Doses greater than 10 milligrams daily have not been shown
to be more effective than 10 milligrams daily. The safety and efficacy of doses greater
than 20 milligrams daily have not been evaluated.
Treatment of bipolar disorder usually is initiated with oral doses of 10-15 milligrams once daily. The dose may be increased by 5 milligrams daily at 24 hour intervals.
Doses greater than 20 milligrams daily have not been evaluated. In clinical trials, doses of 5-20 milligrams daily were effective.
The usual dose for treating agitation due to schizophrenia or bipolar disorder is 10 milligrams administered by intramuscular injection. Additional 10 milligrams doses may be administered, but the efficacy of total daily doses greater than 30 milligrams daily have not been adequately evaluated.
The usual starting dose is 5 to 10 mg once a day. If you start at the lower dose, after a few days the doctor will increase it to 10. After that, the dosage will be increased no more than once a week, 5 mg at a time, up to a maximum of 20 mg a day.
Those most likely to start at 5 mg are people who are weak, people prone to low blood pressure, and nonsmoking women over 65 (because they tend to have a slow metabolism).
Manic Episodes in Bipolar Disorder
The usual starting dose is 10 to 15 mg once a day. If needed, the dose can be increased every 24 hours by 5 mg a day, up to a maximum daily dose of 20 mg. After the person is stabilized, the doctor may continue maintenance therapy at a dosage range of 5 to 20 mg a day. If Zyprexa is being combined with lithium or valproate (Depakene, Depakote), the usual starting dose is 10 mg once a day.
Side effects seen with Zyprexa include:
- Weight gain;
- Orthostatic hypotension;
- Dry mouth;
- Akathisia (an inability to sit still);
Several disorders of movement also may occur with Zyprexa, for example,
extrapyramidal effects (sudden, often jerky, involuntary motions of the head,
neck, arms, body, or eyes). Tardive dyskinesia (involuntary movements of the
mouth, tongue, jaw, or eyelids) also may occur in 1 in 100 patients receiving
Zyprexa. Some cases can be irreversible. The likelihood of developing tardive
dyskinesia increases with prolonged treatment.
There may be an increased risk of increased blood sugar levels and diabetes
with Zyprexa as well as the other antipsychotic medications in its class.
Patients should be tested during treatment for elevated blood sugar.
Additionally, persons with risk factors for diabetes, including obesity or a
family history of diabetes, should have their fasting levels of blood sugar
tested before starting treatment and periodically throughout treatment to detect
the onset of diabetes. Any patient developing symptoms that suggest diabetes
during treatment should be tested for diabetes.
Zyprexa side effects that you should report to your health care professional or doctor as soon as possible:
- Weight Gain;
- Low Blood Pressure Upon Standing;
- Increased Appetite;
- Dry Mouth;
- Change In Personality;